Directed evolution of enzymes: new biocatalysts for asymmetric synthesis.

Marina Alexeeva, Reuben Carr, Nicholas J Turner

Journal: Organic & biomolecular chemistry 2004;1(23):4133-7

PMID: 14685314

Abstract

Directed evolution has been employed to generate new enzymes for the deracemisation of chiral amines.

Address: School of Chemistry, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh, UK EH9 3JJ.

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MeSH Terms: Amine Oxidase (Copper-Containing), Catalysis, Directed Molecular Evolution, Gene Library, Stereoisomerism