Efficient uremic toxins adsorption from simulated blood by immobilization of metal organic frameworks anchored Sephadex beads.

Reda M Abdelhameed, Mahmoud El-Shahat, Bahira Hegazi, Hassan Abdel-Gawad

Journal: Scientific reports 2025;15(1):9667

PMID: 40113799

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Abstract

The current study outlines the removal of Creatinine, p-Cresol sulfate, and Hippuric acid from simulated blood using three new granules: Fe-BTC@Sephadex, Cu-BTC@Sephadex, and Co-BTC@Sephadex. Beads were used to adsorbed toxic chemicals, and the effects of various experimental parameters were examined in the adsorption optimization process. The framework's adsorption isotherms were explained by the application of the Freundlich and Langmuir models. The kinetics of adsorption is represented by a pseudo-first and second-order equation. The morphology and structure of the Fe-BTC@ Sephadex, Co-BTC@ Sephadex, and Cu-BTC@Sephadex beads were investigated using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and X-ray diffraction (XRD). The adsorption capacities for creatinine were 545.69, 339.76, and 189.88 mg/g for Fe-BTC@ Sephadex, Cu-BTC@ Sephadex, and Co-BTC@ Sephadex, respectively, according to the results; the corresponding adsorption capacities for hippuric acid were 323.78, 206.79, and 68.059 mg/g, and the maximum adsorption capacities for p-Cresol sulfate were 122.65, 71.268, and 40.347 mg/g, respectively. These were, in fact, promising findings that have implications for an industrial-scale transportable artificial kidney.

Address: Applied Organic Chemistry Department, Chemical Industries Research Institute, National Research Centre, Scopus affiliation ID 60014618, 33 EL Buhouth St. , Dokki, Giza, 12622, Egypt. [email protected].; Photochemistry Department, Chemical Industries Research Institute, National Research Centre, Scopus affiliation ID 60014618, 33 EL Buhouth St., Dokki, Giza, 12622, Egypt.; Applied Organic Chemistry Department, Chemical Industries Research Institute, National Research Centre, Scopus affiliation ID 60014618, 33 EL Buhouth St. , Dokki, Giza, 12622, Egypt.; Applied Organic Chemistry Department, Chemical Industries Research Institute, National Research Centre, Scopus affiliation ID 60014618, 33 EL Buhouth St. , Dokki, Giza, 12622, Egypt. [email protected].

DOI: 10.1038/s41598-025-92492-w

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MeSH Terms: Metal-Organic Frameworks, Adsorption, Uremic Toxins, Cresols, Hippurates, Spectroscopy, Fourier Transform Infrared, Creatinine, Humans, Kinetics, Sulfuric Acid Esters, X-Ray Diffraction