Effect of CYP2R1 and GC gene polymorphisms on serum 25(OH)D response to vitamin D supplementation in prediabetes.

Yaping Liu, Yujing Zhang, Dongdong Zhang, Peng Ni, Wenjie Li, Xing Li, Ze Xu, Hongwei Wen

Journal: European journal of clinical nutrition 2025;79(8):770-773

PMID: 40114038

Full Text on Nature Publishing Group View on PubMed

Abstract

BACKGROUND

Prediabetes is a crucial period for preventing and managing diabetes. This study aimed to explore the effects of CYP2R1/GC gene polymorphisms on vitamin D supplementation responsiveness in prediabetes.

METHODS

A total of 240 prediabetic participants received orally 1600 IU of vitamin D or placebo daily for 24 weeks.

RESULTS

CYP2R1 rs12794714 AA carriers had less increased 25(OH)D levels compared with GG carriers after supplementation (3.42 (0.05, 6.79) vs. 8.49 (6.14, 10.83), P = 0.038). Moreover, GC rs4588 GA carriers had less increased 25(OH)D levels compared with GG carriers (4.71 (2.64, 6.79) vs. 8.17 (6.37, 9.98), P = 0.033); it also had lower supplementation responsiveness (0.35 (0.14, 0.91), P = 0.032). GC rs4752 AG carriers had higher supplementation responsiveness compared with AA carriers (3.48 (1.05, 11.59), P = 0.042).

CONCLUSIONS

The results indicated that CYP2R1 rs12794714, GC rs4588, and GC rs4752 polymorphism were associated with vitamin D supplementation responsiveness in prediabetes.

Address: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.; Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.; Department of Public Health, Zhengzhou Shuqing Medical College, Zhengzhou, Henan, China.; Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China. [email protected].; Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China. [email protected].

DOI: 10.1038/s41430-024-01564-z

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Full Text Sources:

https://doi.org/10.1038/s41430-024-01564-z

MeSH Terms: Adult, Aged, Female, Humans, Male, Middle Aged, Cholecalciferol, Cholestanetriol 26-Monooxygenase, Cytochrome P450 Family 2, Dietary Supplements, Polymorphism, Single Nucleotide, Prediabetic State, Vitamin D-Binding Protein