Sodium channel blockers for the treatment of focal epilepsy: A Chinese expert consensus.

Zhen Hong, Xintong Wu, Suiqiang Zhu, Shuizhen Zhou, Xiong Han, Meiping Ding, Weiping Liao, Hesheng Zhang, Raowei Yan, Yanchun Deng, Guoxing Zhu, Xin Wang, Kai Zhang, Xiaoshan Wang, Peimin Yu, Dong Zhou, Xuefeng Wang, Xuewu Liu, Xiaorong Liu, Jian Zhou, Bo Xiao, Yuping Wang, Liemin Zhou, Weihong Lin, Tiancheng Wang, Xiangqing Wang, Shuli Liang

Journal: Seizure 2025;127():105-114

PMID: 40121855

Abstract

PURPOSE

To provide consensus-based recommendations for the use of sodium channel blockers (SCBs) in the management of focal epilepsy.

METHODS

A three-round modified Delphi procedure was conducted among a Delphi panel of 24 Chinese experts to build a consensus. A steering committee developed 9 statements related to SCBs for the treatment of focal epilepsy, and these statements were evaluated and voted upon by the expert panel.

RESULTS

The expert panel achieved consensus on nine statements regarding the treatment recommendations for oxcarbazepine, lamotrigine, lacosamide, eslicarbazepine, topiramate, zonisamide and cenobamate in focal epilepsy patients and treatment adjustments for SCBs.

CONCLUSION

This is a Chinese expert consensus on the use of SCBs in focal epilepsy developed using the modified Delphi method. These recommendations can help clinicians in their practice and guide future research.

Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.

Address: Department of Neurology, West China Hospital of Sichuan University, Chengdu, PR China, 610041.; Department of Neurology, Huashan Hospital of Fudan University, Shanghai, PR China, 200040.; Institute of Neuroscience and Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China, 510260.; Department of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China, 400016.; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, PR China, 100053.; Department of Neurology, Xiangya Hospital of Central South University, Changsha, PR China, 410031.; Shanxi Xijing Institute of Epilepsy and Brain Disease, Xi'an, PR China, 710000.; Department of Neurology, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, PR China, 310009.; Department of Neurology, Henan Provincial People's Hospital, Zhengzhou, PR China, 450003.; Department of Functional Neurosurgery, Beijing Children's Hospital, Capital Medical University, Beijing, PR China, 100045.; Department of Neurology, The First Bethune Hospital of Jilin University, Changchun, PR China, 130021.; Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China, 510260.; Department of Neurology, Provincial Hospital Affiliated to Shandong First Medical University, Jinan, PR China, 250001.; Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, PR China, 200032.; Epilepsy Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, PR China, 730030.; Department of Neurology, The First Medical Center of Chinese PLA General Hospital, Beijing, PR China, 100000.; Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, PR China, 210029.; Epilepsy Surgery Ward, Department of Neurosurgery, Beijing Tiantan Hospital, Beijing, PR China, 100070.; Department of Functional Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, PR China, 100080.; Neuromedical Center, The Seventh Affiliated Hospital of Sun Yet-sun University, Shenzhen, PR China, 518000.; Department of Neurology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, PR China, 201102.; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China, 430030.; Department of Neurology, West China Hospital of Sichuan University, Chengdu, PR China, 610041. Electronic address: [email protected].; Department of Neurology, West China Hospital of Sichuan University, Chengdu, PR China, 610041. Electronic address: [email protected].

Link outs

Bant logo

© Copyright 2026, Nutrition Evidence

NED wishes to thank the following organisations for their support:

We use cookies to improve your experience and analyze site traffic with Google Analytics. By continuing to use our site, you agree to our use of cookies. Learn more.