An overview of engineering microbial production of nicotinamide mononucleotide.

Xiangfeng Meng, Weifeng Liu, Boting Li

Journal: Journal of biotechnology 2024;396():80-88

PMID: 39491727

Full Text on Elsevier Science View on PubMed

Abstract

As the human body gradually ages, the cellular level of NAD will decline, which has been found to be related to a variety of age-related diseases. As a precursor of NAD, NMN is able to effectively promote the synthesis of NAD with no significant side effects. Microbial production of NMN holds the potential to lower the production cost and facilitate its wide application. In this review, based on the metabolic pathway of NAD, we summarize recent advances of metabolic engineering strategies for NMN biosynthesis. An outlook for future optimization to improve NMN production is also discussed.

Address: State Key Laboratory of Microbial Technology, Microbiology Technology Institute, Shandong University, No. 72 Binhai Road, Qingdao 266237, PR China.; State Key Laboratory of Microbial Technology, Microbiology Technology Institute, Shandong University, No. 72 Binhai Road, Qingdao 266237, PR China. Electronic address: [email protected].

DOI: 10.1016/j.jbiotec.2024.10.014

Link outs

Free resources

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0168...

MeSH Terms: Metabolic Engineering, Nicotinamide Mononucleotide, NAD, Metabolic Networks and Pathways, Humans