CFTR and bicarbonate secretion by [correction of to] epithelial cells.

Martin J Hug, Tsutomu Tamada, Robert J Bridges

Journal: News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society 2003;18():38-42

PMID: 12531931

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Abstract

Defective HCO(3)(-) and fluid secretion are hallmarks of the pathophysiology of the pancreas of cystic fibrosis patients. Recently, impaired HCO(3)(-) secretion has been shown in most tissues known to express the cystic fibrosis transmembrane conductance regulator (CFTR). New results suggest that CFTR plays an important role in the transcellular secretion of HCO(3)(-).

Address: Institute of Physiology, University of Münster, D-48149 Münster, Germany.

DOI: 10.1152/nips.01412.2002

MeSH Terms: Bicarbonates, Cystic Fibrosis Transmembrane Conductance Regulator, Epithelial Cells, Humans