Targeted isolation of piperazate-containing molecules: bioinformatics and spectroscopy.

Katherine S Ryan, Raymond J Andersen, Mostafa Hagar, Sangwook Kang, Dong-Chan Oh

Journal: Current opinion in microbiology 2025;84():102584

PMID: 39956039

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Abstract

Piperazic acid (Piz) is an intriguing hydrazine-containing amino acid found in a diverse variety of natural products, the majority of which are bioactive. Recently, several approaches have been reported for targeted isolation of Piz-containing molecules, combining spectroscopic techniques for screening Piz moieties with recent advances in Piz biosynthesis. Here, we highlight bioactive natural products recently isolated using these methods and bring into focus structural elucidation challenges impeding the discovery of more Piz-containing molecules.

Address: Department of Chemistry, University of British Columbia, Vancouver, Canada; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada.; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.; Department of Chemistry, University of British Columbia, Vancouver, Canada; Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, Canada.; Department of Chemistry, University of British Columbia, Vancouver, Canada. Electronic address: [email protected].

DOI: 10.1016/j.mib.2025.102584

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MeSH Terms: Computational Biology, Hydrazines, Biological Products, Spectrum Analysis