Renal aquaporin water channels: from molecules to human disease.

Robert W Schrier, Melissa A Cadnapaphornchai

Journal: Progress in biophysics and molecular biology 2003;81(2):117-31

PMID: 12565698

Free Full Text on Elsevier Science View on PubMed

Abstract

Following the discovery of the aquaporin-1 water channel in 1991, molecular techniques have been developed to examine the roles of renal aquaporins-1, -2, -3, and -4 in disorders of water balance. This article reviews current knowledge regarding aquaporin function and dysfunction in water-losing and water-retaining states.

Address: Department of Medicine, University of Colorado School of Medicine, 4200 East Ninth Avenue, Box B178, Denver, CO 80262, USA. [email protected]

DOI: 10.1016/s0079-6107(02)00049-4

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MeSH Terms: Aquaporin 1, Aquaporin 2, Aquaporin 3, Aquaporin 4, Aquaporin 6, Aquaporins, Blood Group Antigens, Diabetes Insipidus, Humans, Kidney, Models, Biological, Models, Molecular, Water, Water-Electrolyte Imbalance