Arezoo Maleki-Hajiagha, Faraz Mojab, Leila Amini, Fardin Amidi
Journal: BMC complementary medicine and therapies 2025;25(1):114
PMID: 40141012
Polycystic ovary syndrome (PCOS) is a condition that can affect hormone levels and metabolism. There are few medicines which can effectively target the disruptions associated with PCOS without considerable side effects and so interest in natural therapies has increased. This study investigated the effects of Salvia officinalis (commonly known as sage) on lipid (fat) levels and oxidative stress (an imbalance between free radicals and antioxidants in the body) in women with PCOS. The researchers conducted a randomised placebo-controlled trial, meaning that some participants received the sage treatment while others received a placebo (a non-active substance), to compare the outcomes effectively.
The findings suggest that S. officinalis may have beneficial effects on some lipids and oxidative stress markers in individuals with PCOS.
It was concluded that S. officinalis may have a potential role in managing metabolic issues associated with PCOS. The study highlights the importance of exploring natural remedies for health conditions like PCOS, which often involve complex metabolic challenges. This study could be used by healthcare professionals to understand the potential benefits of Salvia officinalis in managing lipid and oxidative stress markers in patients with polycystic ovary syndrome.
BACKGROUND
Salvia.officinalis (S. officinalis), is recognized for its antihyperlipidemic, metabolism-regulating, and antioxidant properties in diabetic and hyperlipidemic disorders. This study examining its effects on lipid and oxidative stress (OS) markers in patients with Polycystic Ovary Syndrome (PCOS), thereby substantiating its role in managing metabolic disorders.
METHODS
In this randomized placebo-controlled trial was performed in gynecology clinics affiliated to Iran University of Medical Sciences. Accordingly, 70 Iranian married women aged 15-40 years with newly diagnosed PCOS were included. They were randomized to receive either 330 mg of S. officinalis extract or placebo daily for eight weeks. The study outcomes included lipid profile and OS markers.
RESULTS
The study found a significantly lower triglyceride levels and malondialdehyde after eight weeks of S. officinalis extract intake compared to placebo. Also, the mean change of triglyceride, high-density lipoprotein cholesterol, malondialdehyde, and total antioxidant capacity were statistically significant in intervention group.
CONCLUSION
The study demonstrates that S. officinalis extract can significantly reduce triglyceride levels and OS in patients with PCOS, suggesting its potential as an adjunctive natural therapy for managing metabolic and oxidative imbalances associated with this condition. While the extract did not significantly alter other lipid profile markers, the observed improvements highlight the therapeutic promise of S. officinalis. These findings support further investigation into the clinical applications S. officinalis for PCOS and its potential benefits for metabolic health.
TRIAL REGISTRATION
IRCT201504146917N2 on 2015-10-03 (registered while recruiting).
© 2025. The Author(s).
© Copyright 2026, Nutrition Evidence
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