Medial arterial calcification of the lower limbs in diabetes: Time for awareness? A short narrative review.

Agnès Hartemann, Franck Phan, Jean-Michel Davaine, Damien Denimal, Olivier Bourron, Pauline Treca, Hugo Francon

Journal: Diabetes & metabolism 2025;51(1):101586

PMID: 39521119

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Abstract

In patients with diabetes, peripheral arterial disease, particularly below the knee, is associated with medial arterial calcification. This is a frequent and potentially serious complication, affecting all types of diabetes. In recent years, our understanding of the pathophysiology and clinical significance of medial arterial calcification has improved considerably. Here, we offer a short narrative review of the epidemiology, clinical consequences, and pathophysiology of this complication. Now that medial arterial calcification of the lower limbs is better understood, we also focus on the prospect of treatments targeting arterial calcification.

Address: Sorbonne Université, Paris, France; Assistance Publique‑Hôpitaux de Paris (APHP), Department of Vascular Surgery, Pitié-Salpêtrière Hospital, 47‑83 Boulevard de l'Hôpital, France; Institute of Cardiometabolism and Nutrition (ICAN), Paris, France; INSERM UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.; INSERM U1231, Center for Translational and Molecular Medicine, Dijon, France; Dijon Bourgogne University Hospital, Department of Clinical Biochemistry, Dijon, France.; Sorbonne Université, Paris, France; Institute of Cardiometabolism and Nutrition (ICAN), Paris, France; Assistance Publique‑Hôpitaux de Paris (APHP), Department of Diabetology, Pitié-Salpêtrière Hospital, 47‑83 Boulevard de l'Hôpital, France.; Sorbonne Université, Paris, France; Institute of Cardiometabolism and Nutrition (ICAN), Paris, France; INSERM UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France; Assistance Publique‑Hôpitaux de Paris (APHP), Department of Diabetology, Pitié-Salpêtrière Hospital, 47‑83 Boulevard de l'Hôpital, France.; Sorbonne Université, Paris, France; Institute of Cardiometabolism and Nutrition (ICAN), Paris, France; INSERM UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France; Assistance Publique‑Hôpitaux de Paris (APHP), Department of Diabetology, Pitié-Salpêtrière Hospital, 47‑83 Boulevard de l'Hôpital, France. Electronic address: [email protected].

DOI: 10.1016/j.diabet.2024.101586

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MeSH Terms: Humans, Diabetic Angiopathies, Peripheral Arterial Disease, Lower Extremity, Vascular Calcification