Neurological manifestations of hypermagnesemia: a narrative review.

Marina Romozzi, Giuseppe Magro, Federico Tosto, Vincenzo Laterza

Journal: Acta neurologica Belgica 2025;125(2):283-298

PMID: 39392591

Abstract

Hypermagnesemia is a rare but potentially fatal electrolyte disorder. High serum magnesium levels have been associated with the development of neurological manifestations such as dysautonomia, muscle weakness, respiratory failure, and altered level of consciousness from drowsiness to coma. Although rare, some subjects, such as those with chronic renal failure and those taking magnesium supplements or medications, are at risk of developing this condition. Recognizing this electrolyte alteration promptly allows for an immediate initiation of a therapeutic strategy that is often resolutive when addressed in time. This paper aims to review the neurological complications associated with hypermagnesemia, their pathophysiology, and management.

© 2024. The Author(s) under exclusive licence to Belgian Neurological Society.

Address: Department of Neuroscience, "Giovanni Paolo II" Hospital, Catanzaro, Italy.; Department of Medical and Surgical Sciences, Institute of Neurology, Magna Graecia University, Catanzaro, Italy.; Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli N° 8, 00168, Rome, Italy. [email protected].

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