Clinical Efficacy of Calcium Gluconate Combined With Ergometrine Maleate in the Prevention of Uterine Atony-Induced Postpartum Hemorrhage and Their Effects on Coagulation Function.

This study aims to explore the clinical efficacy of calcium gluconate combined with ergometrine maleate in preventing and treating uterine atony-induced postpartum hemorrhage (PPH) and its impacts on coagulation function. Ninety-six postpartum women with uterine atony were randomly assigned into a study group and a control group (48 cases each) using a double-blind method. The control group received calcium gluconate, while the study group received calcium gluconate combined with ergometrine maleate. Postpartum blood loss at 2 and 24 h, hemostasis time, hemoglobin levels, red blood cell (RBC) count, coagulation indices (PT, TT, APTT, D-D, FIB), inflammatory markers (CRP, IL-6, PCT), labor duration, hospital stay, menstruation recovery, stress-related indicators, and blood viscosity were compared. The study group had significantly lower postpartum blood loss, shorter labor stages, and higher hemoglobin levels and RBC counts at 24 h (p < 0.05). Postpartum, PT, TT, APTT, D-D, inflammatory markers, and stress indicators were lower, while FIB was higher in the study group (p < 0.05). The combination of ergometrine maleate and calcium gluconate effectively reduces PPH, improves stress-related inflammation, and shortens hemostasis time, demonstrating significant clinical benefits.

© 2025 APMIS ‐ Journal of Pathology, Microbiology and Immunology.