Herbal drugs in chronic venous disease treatment: An update.

Laura Mercolini, Silvia Bittner Fialová, Martin Doseděl, Marianna Kocsis, Tímea Bencsik, József Szentpéteri, Milan Nagy, Ágnes Farkas, Györgyi Horváth, Szilvia Czigle, Michele Protti, Viktória Lilla Balázs, Kamilla Ács, Adrienn Horváth, Eszter Csikós, Přemysl Mladěnka, Jaroslav Tóth

Journal: Fitoterapia 2024;179():106256

PMID: 39419127

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Abstract

The prevalence of chronic venous disease (CVD) is relatively high, it affects 20-80 % of the population worldwide. CVD may affect any veins in the human body, however, the veins of the lower extremities are the most susceptible to this condition. Among therapeutic possibilities for CVD, mainly chronic venous insufficiency, some medicinal plants (Ruscus aculeatus L., Aesculus hippocastanum L., Centella asiatica (L.) Urb.) and their active compounds (ruscoside, aescin, asiaticoside) or close derivatives also have important places. This review describes shortly the updated knowledge on pathophysiology, clinical manifestations, evaluation, and diagnostics of CVD as well as treatment modalities. The primary focus of this review is on the existing knowledge about botanical medications for treating chronic venous disease (CVD). It covers the chemical makeup of these plant drugs, their pharmacological effects, results from clinical trials involving humans, and any associated safety concerns.

Address: Department of Pharmacognosy, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, Hungary. Electronic address: [email protected].; Department of Pharmacognosy, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, Hungary. Electronic address: [email protected].; Department of Pharmacognosy, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, Hungary. Electronic address: [email protected].; Department of Pharmacognosy, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, Hungary. Electronic address: [email protected].; Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, Hungary. Electronic address: [email protected].; Lacházi Peregi Pharmacy, H-2340 Kiskunlacháza, Hungary.; Department of Pharmacognosy, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, Hungary. Electronic address: [email protected].; Department of Social and Clinical Pharmacy, Faculty of Pharmacy, Charles University, Akademika Heyrovského 1203/8, CZ-500 05 Hradec Králové, Czech Republic. Electronic address: [email protected].; Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University Bratislava, SK-832-32 Bratislava, Slovakia. Electronic address: [email protected].; Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University Bratislava, SK-832-32 Bratislava, Slovakia. Electronic address: [email protected].; Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University Bratislava, SK-832-32 Bratislava, Slovakia. Electronic address: [email protected].; Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University Bratislava, SK-832-32 Bratislava, Slovakia. Electronic address: [email protected].; Research Group of Pharmaco-Toxicological Analysis (PTA Lab), Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, IT-40126 Bologna, Italy. Electronic address: [email protected].; Research Group of Pharmaco-Toxicological Analysis (PTA Lab), Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, IT-40126 Bologna, Italy. Electronic address: [email protected].; Deparment of Pharmacology and Toxicology, Charles University, Akademika Heyrovského 1203/8, CZ-500 05 Hradec Králové, Czech Republic. Electronic address: [email protected].; Institute of Transdisciplinary Discoveries, Medical School, University of Pécs, H-7624 Pécs, Hungary. Electronic address: [email protected].; Department of Pharmacognosy, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, Hungary. Electronic address: [email protected].

DOI: 10.1016/j.fitote.2024.106256

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Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0367...

Medical:

https://medlineplus.gov/herbalmedicine.html

MeSH Terms: Humans, Venous Insufficiency, Chronic Disease, Plants, Medicinal, Phytotherapy, Centella, Aesculus, Ruscus