Clinical Practice Guideline for detection and management of diabetic kidney disease: A consensus report by the Spanish Society of Nephrology.

Beatriz Fernández-Fernández, Nery Sablón, Juan Jose Gorgojo Martínez, Paula Garcia-Sancho, Laia Oliveras, Rafael Santamaría, María Jesús Puchades, Pablo Molina, José Luis Gorriz, Maria Quero, Diana Rodríguez-Espinosa, Marian Goicoechea, Juan Francisco Navarro-González, María José Soler, Clara García-Carro, Nuria Montero, Alberto Martínez-Castelao

Journal: Nefrologia 2025;45 Suppl 1():1-26

PMID: 40222774

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Abstract

To address all the changes in the management of people with diabetes (DM) and chronic kidney disease (CKD), under the auspices of the Spanish Society of Nephrology (SEN), the Spanish Diabetic Nephropathy Study Group (GEENDIAB) decided to publish an updated Clinical Practice Guideline for detection and management of diabetic kidney disease (DKD). It is aimed at a wide audience of clinicians treating diabetes and CKD. The terminology of kidney disease in diabetic patients has evolved toward a more inclusive nomenclature that avoids underdiagnosis of this entity. Thus, the terms "diabetes and kidney disease" and "diabetic kidney disease" are those proposed in the latest KDIGO 2022 guidelines to designate the whole spectrum of patients who can benefit from a comprehensive therapeutic approach only differentiated according to eGFR range and albuminuria. Recommendations have been divided into five main areas of interest: Chapter 1: Screening and diagnosis of diabetic kidney disease, Chapter 2: Metabolic control in people with diabetes and CKD, Chapter 3: Blood pressure control in people with diabetic kidney disease, Chapter 4: Treatment targeting progression of CKD in people with diabetic kidney disease, and Chapter 5: Antiplatelet or anticoagulant therapy in people with diabetes and CKD. World Health Organization (WHO) recommendations for guideline development were followed to report this guideline. Systematic reviews were carried out, with outcome ratings and summaries of findings, and we reported the strength of recommendations following the "Grading of Recommendations Assessment, Development and Evaluation" GRADE evidence profiles.

Address: Department of Nephrology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address: [email protected].; Department of Nephrology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.; Department of Nephrology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain; RICORS2040 Kidney Disease (RD21/0005/0013), Spain.; Department of Nephrology, Hospital Clínico Universitario de València, Universitat de València, València, Spain.; Department of Nephrology, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institute of Research, Barcelona, Spain.; Department of Nephrology and Hypertension, IIS-Fundación Jiménez Díaz, RICORS2040, Department of Medicine, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.; Department of Nephrology, Hospital Universitario Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain.; Department of Endocrinology and Nutrition, Complex Hospitalari Universitari Moises Broggi, Barcelona, Spain.; Department of Nephrology, Hospital General Universitario Gregorio Marañón, RICORS 2040 Kidney Disease, Spain.; Department of Endocrinology and Nutrition, Hospital Universitario Fundación Alcorcón, Madrid, Spain.; Department of Nephrology, FISABIO, Hospital Universitari Dr. Peset, Universitat de València, València, Spain.; Nephrology Unit, Hospital Clínico Universitario de València, Universitat de València, València, Spain.; Department of Nephrology, Hospital Clínic de Barcelona, Barcelona, Spain.; Department of Nephrology, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.; Department of Nephrology, Hospital Universitario Reina Sofía, Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/University of Cordoba, Córdoba, Spain.; Research Unit and Department of Nephrology, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain; RICORS2040 Kidney Disease (RD21/0005/0013), Instituto de Salud Carlos III, Madrid, Spain; Instituto de Tecnologías Biomédicas, Universidad de La Laguna, Tenerife, Spain; Facultad de Ciencias de la Salud, Universidad Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Electronic address: [email protected].

DOI: 10.1016/j.nefroe.2025.04.005

Link outs

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Full Text Sources:

Medical:

https://medlineplus.gov/diabetickidneyproblems.htm...

Miscellaneous:

https://assays.cancer.gov/CPTAC-802

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-EGFR-8

MeSH Terms: Humans, Diabetic Nephropathies, Spain, Nephrology, Renal Insufficiency, Chronic