Mitochondrial Dysfunction in Cardiac Surgery.

Anne D Cherry

Journal: Anesthesiology clinics 2025;43(2):357-375

PMID: 40348547

Full Text on Elsevier Science View on PubMed

Abstract

Mitochondria are key to the cellular response to energetic demands, but are also vital to reactive oxygen species signaling, calcium hemostasis, and regulation of cell death. Cardiac surgical patients with diabetes, heart failure, advanced age, or cardiomyopathies may have underlying mitochondrial dysfunction or be more sensitive to perioperative mitochondrial injury. Mitochondrial dysfunction, due to ischemia/reperfusion injury and an increased systemic inflammatory response due to exposure to cardiopulmonary bypass and surgical tissue trauma, impacts myocardial contractility and predisposes to arrhythmias. Strategies for perioperative mitochondrial protection and recovery include both well-established cardio-protective protocols and targeted therapies that remain under investigation.

Address: Department of Anesthesiology, Duke University School of Medicine, Duke University Medical Center, Box 3094, Durham, NC 27710, USA. Electronic address: [email protected].

DOI: 10.1016/j.anclin.2025.02.004

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MeSH Terms: Humans, Cardiac Surgical Procedures, Mitochondrial Diseases, Mitochondria, Heart, Mitochondria, Myocardial Reperfusion Injury