Orchestrating ROS regulation: coordinated post-translational modification switches in NADPH oxidases.

Wenli Li, Yongliang Zhang, Savithramma P Dinesh-Kumar, Xinyu Zhang, Dingliang Zhang, Chenchen Zhong

Journal: The New phytologist 2024;245(2):510-522

PMID: 39468860

Abstract

Reactive oxygen species (ROS) are among the most important signaling molecules, playing a significant role in plant growth, development, and responses to various environmental stresses. Respiratory burst oxidase homologs (RBOHs) are key enzymes in ROS production. Plants tightly regulate the activation and deactivation of RBOHs through various post-translational modifications (PTMs), including phosphorylation, ubiquitination, S-nitrosylation, and persulfidation. These PTMs fine-tune ROS production, ensuring normal plant growth and development while facilitating rapid responses to abiotic and biotic stresses. This review discusses the effects of different PTMs on RBOH function and their biological relevance. Additionally, we examine the evolutionary conservation of PTM sites and emphasize the complex interplay between multiple PTMs regulating RBOHs.

Address: State Key Laboratory of Plant Environmental Resilience, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.; Department of Plant Biology and The Genome Center, College of Biological Sciences, University of California, Davis, Davis, CA, 95616, USA.

DOI: 10.1111/nph.20231

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https://doi.org/10.1111/nph.20231

MeSH Terms: Protein Processing, Post-Translational, NADPH Oxidases, Reactive Oxygen Species, Plants