Multifunctionality of alkaline phosphatase in ecology and biotechnology.

Federico Baltar, Daniel E M Saavedra

Journal: Current opinion in biotechnology 2025;91():103229

PMID: 39615073

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Abstract

Multifunctional enzymes can significantly impact biotechnological applications by performing activities beyond their primary functions. This review explores the role of the multifunctionality of alkaline phosphatase, a key enzyme in the phosphorus cycle, focusing on the molecular mechanisms influencing its activity and its biotechnological potential. We argue that understanding these aspects can enhance the utility of alkaline phosphatase in research and industry, fostering innovations in enzyme engineering, environmental biotechnology, and metabolic engineering. By exploring enzyme promiscuity, we highlight alkaline phosphatase's versatility, paving the way for advancements in sustainable agriculture, environmental remediation, and clinical diagnostics. Further research will unlock new applications and catalytic efficiencies, driving forward ecological and biotechnological progress.

Address: Department of Functional and Evolutionary Ecology, Bio-Oceanography and Marine Biology Unit, University of Vienna, Vienna, Austria. Electronic address: [email protected].; Shanghai Engineering Research Center of Hadal Science and Technology, College of Marine Sciences, Shanghai Ocean University, Shanghai, China; Department of Functional and Evolutionary Ecology, Bio-Oceanography and Marine Biology Unit, University of Vienna, Vienna, Austria. Electronic address: [email protected].

DOI: 10.1016/j.copbio.2024.103229

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MeSH Terms: Alkaline Phosphatase, Biotechnology, Ecology