MR Imaging of Neurofluids in the Developing Brain.

Ruth O'Gorman Tuura, Nivedita Agarwal, Willemijn Klein

Journal: Neuroimaging clinics of North America 2025;35(2):287-302

PMID: 40210384

Full Text on Elsevier Science View on PubMed

Abstract

The different fluid compartments in the developing brain work together to facilitate the delivery of nutrients, neurotransmitters, and neuromodulators. The cerebrospinal fluid and interstitial fluid are essential for clearing macromolecules from the brain, a process that involves the recently discovered meningeal lymphatics. Disruptions in these interactions can hinder normal brain development. Additionally, alterations in systemic fluid dynamics may contribute to neurologic complications, highlighting the need for a more holistic approach to understanding and treating neurologic diseases. MR imaging techniques show potential for detecting these pathologic processes in pediatric neurologic disorders.

Address: Head of the Neuroradiology Service, Diagnostic Imaging and Neuroradiology Unit, IRCCS Scientific Institute E. Medea, Bosisio Parini (LC), Italy. Electronic address: [email protected].; Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands.; Center for MR Research, University Children's Hospital Zürich, Switzerland.

DOI: 10.1016/j.nic.2024.12.005

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MeSH Terms: Humans, Magnetic Resonance Imaging, Brain, Neuroimaging