Hidradenitis suppurativa pathogenesis: Extrinsic factors.

Simon Francis Thomsen, Valdemar Wendelboe Nielsen, Haley B Naik

Journal: Journal of the American Academy of Dermatology 2024;91(6S):S17-S21

PMID: 39626993

Full Text on Elsevier Science View on PubMed

Abstract

While genetic predisposition and immune dysregulation are recognized as key contributors to the development of hidradenitis suppurativa, accumulating research points to the influence of extrinsic factors in the pathogenesis of this condition. This review explores the roles of mechanical stress, altered skin and gut microbiome, tobacco smoking, diet, and paradoxical drug reactions as drivers of hidradenitis suppurativa onset and progression. A holistic management approach addressing these factors may be encouraged to improve disease outcomes. Further research is needed to fully determine the causal role of these extrinsic factors and their impact on treatment strategies.

Address: Department of Dermato-Venereology & Wound Healing Centre, Copenhagen University Hospital - Bispebjerg & Frederiksberg, Copenhagen, Denmark.; Department of Dermato-Venereology & Wound Healing Centre, Copenhagen University Hospital - Bispebjerg & Frederiksberg, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Dermatology, University of California, San Francisco, San Francisco, California. Electronic address: [email protected].

DOI: 10.1016/j.jaad.2024.07.1524

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MeSH Terms: Humans, Diet, Disease Progression, Gastrointestinal Microbiome, Hidradenitis Suppurativa, Skin, Tobacco Smoking