Cardiac Surgery-Associated Acute Kidney Injury: An Updated Review of Current Preventive Strategies.

Kirolos A Jacob, David E Leaf

Journal: Anesthesiology clinics 2025;43(2):323-356

PMID: 40348546

Full Text on Elsevier Science View on PubMed

Abstract

Acute kidney injury (AKI) is a frequent and often severe postoperative complication following cardiac surgery, which is associated with poor outcomes in both the short and long terms. Numerous randomized clinical trials have been conducted to investigate various strategies for prevention of cardiac surgery-associated AKI. Unfortunately, most trials conducted to date have been negative. However, encouraging results have been reported with several interventions, including preoperative implementation of oxygen delivery-directed perfusion, novel drugs such as teprasiran and amino acids. Many of these studies, however, require validation in larger, multicenter trials, before their routine use in clinical practice can be recommended.

Address: Department of Paediatric Cardiothoracic Surgery, Wilhelmina Children's Hospital, University Medical Center Utrecht, PO Box 85090, Utrecht 3508 AB, the Netherlands. Electronic address: [email protected].; Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA.

DOI: 10.1016/j.anclin.2025.01.001

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MeSH Terms: Humans, Acute Kidney Injury, Cardiac Surgical Procedures, Postoperative Complications