Ralf Jäger, Martin Purpura, Grant M Tinsley, Ashok Godavarthi, Dhananjaya Bhaskarachar
Journal: European journal of nutrition 2024;63(8):3037-3046
PMID: 39237620
Vitamin C is important for many bodily functions, including supporting the immune system, but it can be difficult for the body to absorb effectively. The aim of this randomised control trial of 27 participants (19 men and 8 women) was to examine how well a special form of vitamin C (LipoVantage), delivered in liposomes (fat bubbles that can carry nutrients), is absorbed in the body compared to standard vitamin C.
The results showed that both forms of vitamin C were absorbed by the body. But the liposomal form of vitamin C was absorbed better into the bloodstream and white blood cells than the standard vitamin C.
It was concluded that liposomal vitamin C significantly increased vitamin C absorption in the blood and white blood cells possibly due to the protection the liposomes provide against breakdown in the gut. This study could be used by healthcare professionals to understand the potential benefits of liposomal vitamin C for improving absorption in the body.
PURPOSE
L-Ascorbic acid (vitamin C) is an essential water-soluble vitamin that plays an important role in various physiological functions, including immune health. The stability of vitamin C in the gastrointestinal tract its bioavailability is limited. This study aimed to investigate if a liposomal form of vitamin C can increase absorption compared to standard vitamin C.
METHODS
In a randomized, double-blind, placebo-controlled, crossover fashion, 19 males and 8 females (n = 27; 36.0 ± 5.1 years, 165.0 ± 6.9 cm, 70.6 ± 7.1 kg) ingested a single-dose of placebo (PLA), 500 mg vitamin C (VIT C), and 500 mg liposomal vitamin C (LV-VIT C, LipoVantage, Specnova, LLC, Tyson Corner, VA, USA). Venous blood samples were collected 0, 0.5-, 1-, 1.5-, 2-, 3-, 4-, 6-, 8-, 12-, and 24-hours after ingestion and were analyzed for plasma and leukocyte vitamin C concentration.
RESULTS
VIT C and LV-VIT C demonstrated significantly greater Cmax and AUC in plasma and in leukocytes compared to placebo (p < 0.001). Additionally, LV-VIT C had significantly higher Cmax (plasma + 27%, leukocytes + 20%, p < 0.001) and AUC (plasma + 21%, leukocytes + 8%, p < 0.001) values as compared to VIT C.
CONCLUSION
Liposomal formulation of vitamin C increases absorption into plasma and leukocytes.
TRIAL REGISTRATION
Clinical Trials Registry - India (CTRI/2023/04/051789).
© 2024. The Author(s).
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