Metabolic engineering for the microbial production of 1,3-propanediol.

Charles E Nakamura, Gregory M Whited

Journal: Current opinion in biotechnology 2004;14(5):454-9

PMID: 14580573

Full Text on Elsevier Science View on PubMed

Abstract

Improvements in the biological production of 1,3-propanediol, a key component of an emerging polymer business, have been realized. Utilizing genes from natural strains that produce 1,3-propanediol from glycerol, metabolic engineering has enabled the development of a recombinant strain that utilizes the lower cost feedstock D-glucose. This accomplishment bodes well for future metabolic engineering efforts and, ultimately, for increased societal benefit obtained through the production of chemicals from renewable resources.

Address: DuPont Central Research & Development Experimental Station, 328/245A Wilmington, DE 19880-0328, USA. [email protected]

DOI: 10.1016/j.copbio.2003.08.005

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MeSH Terms: Bacteria, Biological Transport, Catalysis, Cobamides, Fermentation, Glucose, Industrial Microbiology, Propylene Glycols, Protein Engineering