HIS & HERS, magic magnesium and the ballet of protein synthesis.

K Mark Parnell, Scott A Strobel

Journal: Current opinion in chemical biology 2004;7(5):528-33

PMID: 14580554

Full Text on Elsevier Science View on PubMed

Abstract

The peptidyl transferase center of the ribosome is literally the mother of all protein enzymes, yet it was only recently that the content of its active site was found to be RNA and not protein. This review focuses on how this RNA enzyme orients its substrates and promotes the chemical reaction that is center stage in protein synthesis.

Address: Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Ave, New Haven, CT 06520-8114, USA.

DOI: 10.1016/j.cbpa.2003.08.003

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MeSH Terms: Catalysis, Enzyme Stability, Magnesium, Molecular Structure, Peptidyl Transferases, Protein Biosynthesis, RNA, Ribosomal, Ribosomes, Substrate Specificity