Vitamin D-An Ignored Biomarker. Should We Supplement Vitamin D in Insufficient State or Monitor It as an Important Biomarker of MIND Association?

Jayanta Chakraborty, Semanti Chakraborty

Journal: The Journal of the Association of Physicians of India 2024;72(11):e40-e42

PMID: 39563130

Abstract

Vitamin D deficiency has become a global epidemic in the past 2 decades. The present review has enlightened us about the etiopathogenesis of this epidemic. A search of the literature and our previous studies were analyzed, and a conclusion was created. It has been seen that the upsurge of obesity, metabolic syndrome (MetS), nonalcoholic fatty liver disease (NAFLD), and vitamin D deficiency are going hand in hand in all countries of the world. Probably downregulation of the gene , whose product is 25-hydroxylase, may be the causative factor, as the enzyme 25-hydroxylase produces 25-hydroxy vitamin D from both ergocalciferol and cholecalciferol in the liver. Obesity, MetS, insulin resistance, and NAFLD are the causative factors of ubiquitous vitamin D deficiency.

Address: Professor and Director, Department of Endocrinology, Vivekananda Institute of Medical Sciences, Kolkata, West Bengal, India, Orcid: https://orcid.org/0000-0002-0223-2687, Corresponding Author.; Endocrinologist, Department of Endocrinology, Woodlands Multispeciality Hospital, Kolkata, West Bengal, India.

DOI: 10.59556/japi.72.0770

Link outs

Free resources

Medical:

https://medlineplus.gov/fattyliverdisease.html

Miscellaneous:

https://assays.cancer.gov/non-CPTAC-3393

MeSH Terms: Humans, Vitamin D Deficiency, Vitamin D, Non-alcoholic Fatty Liver Disease, Biomarkers, Metabolic Syndrome, Obesity, Dietary Supplements, Insulin Resistance, Cytochrome P450 Family 2, Cholestanetriol 26-Monooxygenase