Resolution of enantiomers of ketoprofen by HPLC: a review.

Ramesh Mullangi, Ming Yao, Nuggehally R Srinivas

Journal: Biomedical chromatography : BMC 2004;17(7):423-34

PMID: 14598325

Abstract

Today, a heightened awareness of the applicability of enantiomers in medicine and clinical practice has been gene-rated due to the continuous evolvement of the field of chirality. In this context, this article provides a review of separation of ketoprofen, an important drug, in a popular class of non-steroidal anti-inflammatory drugs (i.e. profens). This review highlights various methodologies, logistical considerations for separation and provides an exhaustive list of applications mainly focusing on the pharmacokinetic aspects. Clearly, the application of enantioselective methods for drug racemates paves the way to understand the in vivo behavior of individual enantiomer and hence an opportunity for an alternate and/or better option for treating the disease.

Address: Bioanalysis, Metabolism and Pharmacokinetics Laboratories, Discovery Research, Dr. Reddy's Laboratories Ltd., Miyapur, Hyderabad-500 050, India.

DOI: 10.1002/bmc.277

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MeSH Terms: Anti-Inflammatory Agents, Non-Steroidal, Chromatography, High Pressure Liquid, Ketoprofen, Stereoisomerism