Milk fat globule EGF and factor V/VIII domain containing-mediated osteoimmunology in periodontal disease.

Shuang Peng, Ruonan Zhang, Lili Chen, Guangxun Zhu

Journal: American journal of dentistry 2024;37(5):237-243

PMID: 39321103

Abstract

PURPOSE

To review the literature on the relationship of milk fat globule EGF and factor V/VIII domain containing (MFGE8) in periodontal osteoimmunology and the clinical significance of MFGE8 in periodontal disease.

METHODS

Two reviewers carried out a computer-based literature search using PubMed, Scopus, and Web of Science to identify papers published up to November 2023. The keywords used in the investigation were "MFGE8" and various words related to periodontal disease (periodontal, periodontitis, gingival, gingivitis, gingiva, and periodontium).

RESULTS

MFGE8 plays a critical role in the etiology of periodontal disease via regulating pro-inflammatory cytokines and bone cells. In addition, MFGE8 may be applied as a diagnostic biomarker and a therapeutic target in periodontal disease.

CLINICAL SIGNIFICANCE

MFGE8-mediated periodontal osteoimmunology fills the vacant part of the pathogenesis in periodontal disease. This review provides a comprehensive perspective on the potential of MFGE8 in periodontal disease therapy.

Address: Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Endodontics, School and Hospital of Stomatology, Wuhan University, Wuhan, China.; Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, China.; Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, [email protected].

Link outs

Free resources

Miscellaneous:

https://assays.cancer.gov/non-CPTAC-3990

MeSH Terms: Humans, Periodontal Diseases, Milk Proteins, Antigens, Surface, Cytokines, Biomarkers, Periodontitis