A review on tyrosine kinase inhibitors for targeted breast cancer therapy.

Vidya Sankarapandian, Ramya Lakshmi Rajendran, Rajapandiyan Krishnamoorthy, Prakash Gangadaran, Byeong-Cheol Ahn, Conrad Ondieki Miruka, Poornima Sivamani, Balu Alagar Venmathi Maran

Journal: Pathology, research and practice 2024;263():155607

PMID: 39326367

Full Text on Elsevier Science View on PubMed

Abstract

Breast cancer is a heterogeneous disease with complex molecular pathogenesis. Overexpression of several tyrosine kinase receptors is associated with poor prognosis, therefore, they can be key targets in breast cancer therapy. Tyrosine kinase inhibitors (TKIs) have emerged as leading agents in targeted cancer therapy due to their effectiveness in disrupting key molecular pathways involved in tumor growth. TKIs target various tyrosine kinases, including the human epidermal growth factor receptor 2 (HER2), epidermal growth factor receptor (EGFR), Vascular endothelial growth factor receptor (VEGFR), anaplastic lymphoma kinase (ALK), vascular endothelial growth factor receptor (VEGFR)-associated multi-targets, rearranged during transfection (RET), fibroblast growth factor receptor (FGFR), receptor tyrosine kinase-like orphan signal 1 (ROS1), Mitogen-activated protein kinase (MAPK), and tropomyosin receptor kinase (TRK). These drugs target the tyrosine kinase domain of receptor tyrosine kinases and play a vital role in proliferation and migration of breast cancer cells. Several TKIs, including lapatinib, neratinib, and tucatinib, have been developed and are currently used in clinical settings, often in combination with chemotherapy, endocrine therapy, or other targeted agents. TKIs have demonstrated remarkable benefits in enhancing progression-free and overall survival in patients with breast cancer and have become a standard of care for this population. This review provides an overview of TKIs currently being examined in preclinical studies and clinical trials, especially in combination with drugs approved for breast cancer treatment. TKIs have emerged as a promising therapeutic option for patients with breast cancer and hold potential for treating other breast cancer subtypes. The development of new TKIs and their integration into personalized treatment strategies will continue to shape the future of breast cancer therapy.

Address: Department of Microbiology and Immunology, Kampala International University, Western Campus, Box 20000, Uganda.; Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea; Cardiovascular Research Institute, Kyungpook National University, Daegu 41944, Republic of Korea.; Department of Biochemistry, Kampala International University, Western Campus, Box 20000, Uganda.; Department of Pharmacology and Clinical pharmacology, Christian Medical College, Vellore 632004, India.; Graduate School of Integrated Science and Technology, Nagasaki University, 1-14 Bunkyomachi, Nagasaki 852-8521, Japan.; Department of Food Science and Nutrition, College of Food and Agriculture Sciences, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia.; Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea; BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea; Cardiovascular Research Institute, Kyungpook National University, Daegu 41944, Republic of Korea.. Electronic address: [email protected].; Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea; BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea; Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu 41944, Republic of Korea; Cardiovascular Research Institute, Kyungpook National University, Daegu 41944, Republic of Korea.. Electronic address: [email protected].

DOI: 10.1016/j.prp.2024.155607

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https://medlineplus.gov/breastcancer.html

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https://assays.cancer.gov/CPTAC-192

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https://antibodies.cancer.gov/detail/CPTC-EGFR-8

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Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0344...

MeSH Terms: Humans, Breast Neoplasms, Protein Kinase Inhibitors, Female, Molecular Targeted Therapy, Antineoplastic Agents, Tyrosine Kinase Inhibitors