History, Advances, and Challenges of Sickle Cell Disease Treatment.

Kleber Y Fertrin, Ritika Walia, Daniel E Sabath

Journal: Clinics in laboratory medicine 2024;44(4):679-691

PMID: 39490124

Full Text on Elsevier Science View on PubMed

Abstract

Sickle cell disease (SCD) is marked by red blood cells that deform into a sickle shape, causing severe health complications. Historic neglect and slow therapeutic progress have left many, especially African descendants, vulnerable. Recent treatment strides include novel drugs and gene therapy, promising improved management. Nonetheless, challenges persist with treatment adoption because of cost, adverse effects, and accessibility. Advancements hold hope for enhanced life quality and longevity for SCD patients.

Address: Hematopathology Division, Department of Laboratory Medicine and Pathology, University of Washington, 1144 Eastlake Avenue East, LG-200, Seattle, WA 98109, USA. Electronic address: [email protected].; Sickle Cell Disease and Iron Overload Program, Fred Hutch Cancer Center, 825 Eastlake Avenue East, MS LG700, Seattle, WA 98109, USA.; Hematology Division, Department of Laboratory Medicine and Pathology, University of Washington, Harborview Medical Center, 3NJ345.1, Box 359743, 325 9th Avenue, Seattle, WA 98104, USA.

DOI: 10.1016/j.cll.2024.07.004

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MeSH Terms: Anemia, Sickle Cell, Humans, Genetic Therapy, Antisickling Agents, History, 20th Century, History, 21st Century