Updates in the Management of Chronic Pancreatitis: Navigating Through Recent Advances.

Petr Vanek, Martin L Freeman

Journal: Gastroenterology clinics of North America 2025;54(1):157-174

PMID: 39880525

Full Text on Elsevier Science View on PubMed

Abstract

This article provides an up-to-date review of the management of chronic pancreatitis, highlighting advancements in medical therapy, nutritional support, endoscopic and surgical approaches, and emerging treatments. Nutritional management accentuates addressing malabsorption and nutrient deficiencies. Advances in endoscopy and parenchyma-sparing surgical techniques have opened new avenues for improved patient outcomes, with total pancreatectomy and islet autotransplantation offering the only definitive solution for selected patients. Additionally, emerging therapies, including anti-inflammatory and immune-modulating agents, show promise for future treatment options. Emphasizing a multidisciplinary approach, this review aims to equip health care professionals with a comprehensive overview of current management strategies and future directions.

Address: Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77900 Olomouc, Czech Republic; Department of Gastroenterology and Digestive Endoscopy, Masaryk Memorial Cancer Institute, Zluty Kopec 7, 65653 Brno, Czech Republic.; Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA. Electronic address: [email protected].

DOI: 10.1016/j.gtc.2024.08.008

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MeSH Terms: Humans, Pancreatitis, Chronic, Pancreatectomy, Nutritional Support, Islets of Langerhans Transplantation