Cytokinesis: a logical GAP.

Masanori Mishima, Michael Glotzer

Journal: Current biology : CB 2004;13(15):R589-91

PMID: 12906808

Free Full Text on Elsevier Science View on PubMed

Abstract

Two complexes localize to the central spindle and regulate completion of cytokinesis: one, centralspindlin, contains a kinesin-like protein and a Rho-family GAP; the second contains Aurora B kinase. Aurora B kinase is known to regulate localization of centralspindlin and may regulate the activity of the RhoGAP component of centralspindlin.

Address: Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030, Vienna, Austria.

DOI: 10.1016/s0960-9822(03)00521-9

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MeSH Terms: Amino Acid Sequence, Aurora Kinases, Cell Division, GTPase-Activating Proteins, Microtubule-Associated Proteins, Microtubules, Molecular Sequence Data, Protein Serine-Threonine Kinases, Spindle Apparatus