Corticotropin-releasing hormone and obesity: From fetal life to adulthood.

Madalena von Hafe, Adelino Leite-Moreira, Rui Adão, Inês Vasconcelos, Carmen Brás-Silva

Journal: Obesity reviews : an official journal of the International Association for the Study of Obesity 2024;25(8):e13763

PMID: 38699883

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Abstract

Obesity is among the most common chronic disorders, worldwide. It is a complex disease that reflects the interactions between environmental influences, multiple genetic allelic variants, and behavioral factors. Recent developments have also shown that biological conditions in utero play an important role in the programming of energy homeostasis systems and might have an impact on obesity and metabolic disease risk. The corticotropin-releasing hormone (CRH) family of neuropeptides, as a central element of energy homeostasis, has been evaluated for its role in the pathophysiology of obesity. This review aims to summarize the relevance and effects of the CRH family of peptides in the pathophysiology of obesity spanning from fetal life to adulthood.

Address: Cardiovascular R&D Centre-UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.; Cardiovascular R&D Centre-UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.; Department of Pharmacology and Toxicology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.; CIBER Enfermedades Respiratorias (Ciberes), Madrid, Spain.; Cardiovascular R&D Centre-UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.; Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal.

DOI: 10.1111/obr.13763

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MeSH Terms: Humans, Corticotropin-Releasing Hormone, Obesity, Pregnancy, Female, Energy Metabolism, Adult, Prenatal Exposure Delayed Effects, Homeostasis