Hepatoprotective dibenzocyclooctadiene lignans from the fruits of Kadsura coccinea.

Hanli Ruan, Jian Liu, Wenming Wu, An Jin

Journal: Fitoterapia 2024;178():106184

PMID: 39142529

Full Text on Elsevier Science View on PubMed

Abstract

The phytochemical investigations on the fruits of Kadsura coccinea led to the isolation of six undescribed dibenzocyclooctadiene lignans named kadcolignans B-G, together with eleven previously described analogues. The structures of these compounds were established by spectroscopic methods including NMR, HRESIMS, and CD experiments. All isolated compounds were evaluated for their hepatoprotective activity by measuring the levels of triglyceride (TG), total cholesterol (TC), and reactive oxygen species (ROS) in FFA-induced HepG2 cells. As a result, compounds 4, 5, 9, 13, and 15 showed potent inhibitory effects on hepatocyte lipid accumulation at a concentration of 100 μM. Our research not only broadens the understanding on the chemical composition of K. coccinea but also provides experimental and theoretical evidences supporting the fruit's active ingredients in alleviating nonalcoholic fatty liver disease (NAFLD).

Address: Department of Pharmacy, Jiangxi provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, China.; School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China; School of Pharmaceutical Science, University of South China, Hengyang 421001, Hunan Province, China.; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, China.; School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China; School of Pharmaceutical Science, University of South China, Hengyang 421001, Hunan Province, China. Electronic address: [email protected].

DOI: 10.1016/j.fitote.2024.106184

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MeSH Terms: Lignans, Fruit, Humans, Kadsura, Hep G2 Cells, Cyclooctanes, Molecular Structure, Phytochemicals, Protective Agents, Reactive Oxygen Species, Triglycerides, China, Cholesterol, Non-alcoholic Fatty Liver Disease