Nuclear receptors: a rendezvous for chromatin remodeling factors.

Borja Belandia, Malcolm G Parker

Journal: Cell 2003;114(3):277-80

PMID: 12914692

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Abstract

Nuclear receptors (NRs) are a large family of ligand-induced transcription factors that include the vitamin D receptor. The recent discovery of WINAC, a novel ATP-dependent chromatin remodeling complex, has shed new light on the molecular mechanisms by which the vitamin D receptor controls gene expression with unexpected clinical implications.

Address: Institute of Reproductive and Developmental Biology, Imperial College London, Faculty of Medicine, Du Cane Road, London, W12 ONN, United Kingdom.

DOI: 10.1016/s0092-8674(03)00599-3

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http://hdl.handle.net/10261/80112
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MeSH Terms: Chromatin, Humans, Models, Genetic, Receptors, Cytoplasmic and Nuclear, Transcription Factors, Vitamin D, Williams Syndrome