Evidence-based sports supplements: A redox analysis.

Paraskevi Kritsiligkou, James N Cobley, Konstantinos Papanikolaou, Michalis G Nikolaidis, Nikos V Margaritelis, George G Nastos, Stephen J Bailey

Journal: Free radical biology & medicine 2024;224():62-77

PMID: 39147071

Full Text on Elsevier Science View on PubMed

Abstract

Despite the overwhelming number of sports supplements on the market, only seven are currently recognized as effective. Biological functions are largely regulated through redox reactions, yet no comprehensive analysis of the redox properties of these supplements has been compiled. Here, we analyze the redox characteristics of these seven supplements: bicarbonates, beta-alanine, caffeine, creatine, nitrates, carbohydrates, and proteins. Our findings suggest that all sports supplements exhibit some degree of redox activity. However, the precise physiological implications of these redox properties remain unclear. Future research, employing unconventional perspectives and methodologies, will reveal new redox pixels of the exercise physiology and sports nutrition picture.

Address: Department of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Serres, Greece. Electronic address: [email protected].; School of Life Sciences, The University of Dundee, Dundee, Scotland, UK.; Department of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Serres, Greece.; Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.; Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.

DOI: 10.1016/j.freeradbiomed.2024.08.012

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MeSH Terms: Oxidation-Reduction, Dietary Supplements, Humans, Caffeine, beta-Alanine, Creatine, Nitrates