Honokiol and magnolol: A review of structure-activity relationships of their derivatives.

Yi-Hui Yang, Si-Yang Dai, Yue-Hu Pei, Shuo Yu, Chang Li, Wen-Xiu Qin

Journal: Phytochemistry 2024;223():114132

PMID: 38714288

Full Text on Elsevier Science View on PubMed

Abstract

Honokiol (HK) and magnolol (MAG) are typical representatives of neolignans possessing a wide range of biological activities and are employed as traditional medicines in Asia. In the past few decades, HK and MAG have been proven to be promising chemical scaffolds for the development of novel neolignan drugs. This review focuses on recent advances in the medicinal chemistry of HK and MAG derivatives, especially their structure-activity relationships. In addition, it also presents a comprehensive summary of the pharmacology, biosynthetic pathways, and metabolic characteristics of HK and MAG. This review can provide pharmaceutical chemists deeper insights into medicinal research on HK and MAG, and a reference for the rational design of HK and MAG derivatives.

Address: Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, 150081, PR China.; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, 150081, PR China. Electronic address: [email protected].; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, 150081, PR China. Electronic address: [email protected].

DOI: 10.1016/j.phytochem.2024.114132

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MeSH Terms: Lignans, Biphenyl Compounds, Structure-Activity Relationship, Humans, Molecular Structure, Allyl Compounds, Phenols