Kathrine J Vinknes, Anders Åsberg, Amany Elshorbagy, Kjetil Retterstøl, Nasser E Bastani, Thomas Olsen, Helga Refsum, Emma Stolt, Hasse K Zaré
Journal: Amino acids 2024;56(1):39
PMID: 38844567
Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known whether it interferes with metabolism of other amino acids or protein. In this Phase-1 study, we show that a single dose of mesna administered at 400, 800, 1200 or 1600 mg to 6-7 individuals per dose only slightly affects amino acid profiles, with increases in plasma valine across dose levels. There were no effects of mesna on 3-methylhistidine, a marker of protein breakdown.
© 2024. The Author(s).
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