Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study.

Kathrine J Vinknes, Anders Åsberg, Amany Elshorbagy, Kjetil Retterstøl, Nasser E Bastani, Thomas Olsen, Helga Refsum, Emma Stolt, Hasse K Zaré

Journal: Amino acids 2024;56(1):39

PMID: 38844567

Abstract

Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known whether it interferes with metabolism of other amino acids or protein. In this Phase-1 study, we show that a single dose of mesna administered at 400, 800, 1200 or 1600 mg to 6-7 individuals per dose only slightly affects amino acid profiles, with increases in plasma valine across dose levels. There were no effects of mesna on 3-methylhistidine, a marker of protein breakdown.

© 2024. The Author(s).

Address: Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway. [email protected].; Department of Pharmacology, University of Oxford, Oxford, UK.; Department of Physiology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.; Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway.; Department of Pharmacy, University of Oslo, Oslo, Norway.; Department of Pharmacology, Oslo University Hospital, Oslo, Norway.; Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Physiology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.; Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Endocrinology, The Lipid Clinic, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.
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