Genetic dissection of the bacterial Fe-S protein biogenesis machineries.

Corinne Aubert, Pierre Mandin, Béatrice Py, Mathieu Sourice, Charlotte Oriol

Journal: Biochimica et biophysica acta. Molecular cell research 2024;1871(5):119746

PMID: 38719030

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Abstract

Iron‑sulfur (Fe-S) clusters are one of the most ancient and versatile inorganic cofactors present in the three domains of life. Fe-S clusters are essential cofactors for the activity of a large variety of metalloproteins that play crucial physiological roles. Fe-S protein biogenesis is a complex process that starts with the acquisition of the elements (iron and sulfur atoms) and their assembly into an Fe-S cluster that is subsequently inserted into the target proteins. The Fe-S protein biogenesis is ensured by multiproteic systems conserved across all domains of life. Here, we provide an overview on how bacterial genetics approaches have permitted to reveal and dissect the Fe-S protein biogenesis process in vivo.

Address: Laboratoire de Chimie Bactérienne (UMR7283), Institut de Microbiologie de la Méditerranée, Institut Microbiologie Bioénergies et Biotechnologie, Centre National de la Recherche Scientifique, Aix-Marseille Université, Marseille, France.; Laboratoire de Chimie Bactérienne (UMR7283), Institut de Microbiologie de la Méditerranée, Institut Microbiologie Bioénergies et Biotechnologie, Centre National de la Recherche Scientifique, Aix-Marseille Université, Marseille, France. Electronic address: [email protected].

DOI: 10.1016/j.bbamcr.2024.119746

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MeSH Terms: Iron-Sulfur Proteins, Bacterial Proteins, Iron, Sulfur, Bacteria