Integrating nutrition, physical exercise, psychosocial support and antiemetic drugs into CINV management: The road to success.

Luisa Carbognin, Emilio Bria, Alice Avancini, Lorenzo Belluomini, Marco Sposito, Daniela Tregnago, Ilaria Trestini, Jessica Insolda, Michele Milella, Sara Pilotto, Letizia Pontolillo

Journal: Critical reviews in oncology/hematology 2024;201():104444

PMID: 39002789

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Abstract

Over the years, advancements in antiemetic drugs have improved chemotherapy-induced nausea and vomiting (CINV) control. However, despite the antiemetics therapies, in a relevant number of adult patients (∼30 %), CINV is still persistent, leading to several complications, such as electrolyte imbalances, anorexia, and treatment discontinuation. Supportive care interventions have gained credibility in cancer care, helping to improve patients' psycho-physical condition, quality of life, and managing symptoms, including CINV. Physical exercise and tailored nutritional counseling have demonstrated benefits in reducing the severity of nausea and vomiting. Psychological intervention has been postulated as a key approach in controlling anticipatory nausea/vomiting, as well as acupuncture/acupressure has been shown to decrease nausea and vomiting after chemotherapy treatments. In the current review, we aim to provide a clinical update on current prophylactic and delayed antiemetic guidelines for CINV and an overview of the non-pharmacological interventions tested for alleviating CINV in patients with cancer.

Address: Section of Innovation Biomedicine, Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, Italy. Electronic address: [email protected].; Section of Innovation Biomedicine, Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, Italy. Electronic address: [email protected].; Section of Innovation Biomedicine, Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, Italy. Electronic address: [email protected].; UOC Oncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy; Medical Oncology, Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Roma, Italy. Electronic address: [email protected].; Section of Innovation Biomedicine, Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, Italy. Electronic address: [email protected].; Dietetic Service, Hospital Medical Direction, University and Hospital Trust (AOUI) of Verona, Italy. Electronic address: [email protected].; Section of Innovation Biomedicine, Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, Italy. Electronic address: [email protected].; UOC Oncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy; Medical Oncology, Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Roma, Italy. Electronic address: [email protected].; Section of Innovation Biomedicine, Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, Italy. Electronic address: [email protected].; UOC Oncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy; Medical Oncology, Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Roma, Italy. Electronic address: [email protected].; Section of Innovation Biomedicine, Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, Italy. Electronic address: [email protected].

DOI: 10.1016/j.critrevonc.2024.104444

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MeSH Terms: Humans, Antiemetics, Nausea, Vomiting, Exercise, Neoplasms, Antineoplastic Agents, Psychosocial Support Systems, Quality of Life