Intestinal Transplant for Hirschsprung's Disease: Stoma for Life or Not?

Geoffrey James Bond

Journal: Gastroenterology clinics of North America 2024;53(2):289-297

PMID: 38719379

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Abstract

Hirschsprung's disease is a dysmotility disease caused by lack of ganglion cells in the bowel wall that can affect varying lengths of the intestine. In extreme circumstances, there can be little remaining ganglionated bowel, and the patient becomes dependent on parental nutrition (PN) for survival. Intestinal transplant has been utilized to salvage these patients suffering terminal complications of PN. The question as to whether to reestablish intestinal continuity, and thus not require a stoma is vexed. However, data and experience would suggest this can be safely done with good functional results.

Address: Surgical Director, ICARE Children's Hospital of Pittsburgh of UPMC, 4401 Penn Avenue, 6FP Pittsburgh, PA 15224, USA. Electronic address: [email protected].

DOI: 10.1016/j.gtc.2024.03.002

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MeSH Terms: Hirschsprung Disease, Humans, Intestines, Surgical Stomas