Astronaut omics and the impact of space on the human body at scale.

Saswati Das, Richard Barker, Daniela Bezdan, Henry Cope, Sylvain V Costes, Stefania Giacomello, Nathaniel J Szewczyk, Masafumi Muratani, Deanne M Taylor, Christopher E Mason, Lindsay A Rutter, Matthew J MacKay, Amber M Paul, Raúl Herranz, Sergey A Ponomarev

Journal: Nature communications 2024;15(1):4952

PMID: 38862505

Abstract

Future multi-year crewed planetary missions will motivate advances in aerospace nutrition and telehealth. On Earth, the Human Cell Atlas project aims to spatially map all cell types in the human body. Here, we propose that a parallel Human Cell Space Atlas could serve as an openly available, global resource for space life science research. As humanity becomes increasingly spacefaring, high-resolution omics on orbit could permit an advent of precision spaceflight healthcare. Alongside the scientific potential, we consider the complex ethical, cultural, and legal challenges intrinsic to the human space omics discipline, and how philosophical frameworks may benefit from international perspectives.

© 2024. The Author(s).

Address: Transborder Medical Research Center, University of Tsukuba, 305-8575, Tsukuba, Japan.; Department of Genome Biology, Institute of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan.; School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK.; School of Medicine, University of Nottingham, Derby, DE22 3DT, UK.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 10065, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, 10021, USA.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, 10065, USA.; Centro de Investigaciones Biológicas "Margarita Salas" (CSIC), Ramiro de Maeztu 9, Madrid, 28040, Spain.; Department of Biochemistry, Atal Bihari Vajpayee Institute of Medical Sciences & Dr. Ram Manohar Lohia Hospital, New Delhi, 110001, India.; Department of Immunology and Microbiology, Institute for the Biomedical Problems, Russian Academy of Sciences, 123007, Moscow, Russia.; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, 94035, USA.; Embry-Riddle Aeronautical University, Department of Human Factors and Behavioral Neurobiology, Daytona Beach, FL, 32114, USA.; Department of Botany, University of Wisconsin-Madison, Madison, WI, 53706, USA.; Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, 72076, Germany.; NGS Competence Center Tübingen (NCCT), University of Tübingen, Tübingen, 72076, Germany.; yuri GmbH, Meckenbeuren, 88074, Germany.; School of Medicine, University of Nottingham, Derby, DE22 3DT, UK.; Ohio Musculoskeletal and Neurological Institute (OMNI), Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, 45701, USA.; Transborder Medical Research Center, University of Tsukuba, 305-8575, Tsukuba, Japan.; Department of Genome Biology, Institute of Medicine, University of Tsukuba, 305-8575, Tsukuba, Japan.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 10065, USA. [email protected].; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, 10021, USA. [email protected].; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, 10065, USA. [email protected].; The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, 10065, USA. [email protected].; SciLifeLab, KTH Royal Institute of Technology, Stockholm, 17165, Sweden. [email protected].
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