Recent Advances and Future Developments in the Preparation of Polypeptides via -Carboxyanhydride (NCA) Ring-Opening Polymerization.

Wenhui Dai, Kang Chen, Yueming Wu, Jiangzhou Wang, Minzhang Chen, Runhui Liu

Journal: Journal of the American Chemical Society 2024;146(35):24189-24208

PMID: 39172171

Full Text on American Chemical Society View on PubMed

Abstract

Polypeptides have the same or similar backbone structures as proteins and peptides, rendering them as suitable and important biomaterials. Amino acid -carboxyanhydrides (NCA) ring-opening polymerization has been the most efficient strategy for polypeptide preparation, with continuous advance in the design of initiators, catalysts and reaction conditions. This Perspective first summarizes the recent progress of NCA synthesis and purification. Subsequently, we focus on various initiators for NCA polymerization, catalysts for accelerating polymerization or enhancing the controllability of polymerization, and recent advances in the reaction approach of NCA polymerization. Finally, we discuss future research directions and open challenges.

Address: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, Key Laboratory of Specially Functional Polymeric Materials and Related Technology (Ministry of Education), Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, Key Laboratory of Specially Functional Polymeric Materials and Related Technology (Ministry of Education), Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

DOI: 10.1021/jacs.4c05382

Link outs

Subscription / membership required

Full Text Sources:

https://doi.org/10.1021/jacs.4c05382

MeSH Terms: Peptides, Polymerization, Anhydrides, Catalysis, Molecular Structure, Amino Acids