Measurement of cefaclor and amoxicillin-clavulanic acid levels in middle-ear fluid in patients with acute otitis media.

F Scaglione, D Caronzolo, J P Pintucci, F Fraschini

Journal: Antimicrobial agents and chemotherapy 2003;47(9):2987-9

PMID: 12937009

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Abstract

Concentrations of cefaclor (CFC) or amoxicillin-clavulanic acid (AMX/CA) in middle-ear fluid collected preserving the stability and clearing the cell contents has been compared to those obtained using the traditional method. Sixty-seven children with effusive otitis media were treated orally with CFC (20 mg/kg of body weight) or AMX/CA (20 mg/kg) (4:1 ratio). The concentrations in cell-free fluid (C-) appear higher than those in the total fluid (C+) (as assayed traditionally).

Address: University of Milan, Milan, Italy. [email protected]

DOI: 10.1128/AAC.47.9.2987-2989.2003

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MeSH Terms: Acute Disease, Adolescent, Amoxicillin-Potassium Clavulanate Combination, Area Under Curve, Body Fluids, Cefaclor, Cephalosporins, Child, Child, Preschool, Chromatography, High Pressure Liquid, Drug Therapy, Combination, Ear, Middle, Female, Humans, Male