A side-by-side comparison of fine-tuning options for treatment of medically refractory epilepsy: Antiseizure medications, vagus nerve stimulation and ketogenic diet therapies.

Deana Bonno, Eric Kossoff, Lisa Vanatta

Journal: Epilepsy research 2024;206():107441

PMID: 39216316

Full Text on Elsevier Science View on PubMed

Abstract

There are many treatment options available for patients with medically refractory epilepsy including antiseizure medications, surgery, devices and ketogenic diet therapy. Ketogenic diet therapy has been shown to be a safe and effective treatment option in adult and pediatric patients. In order to obtain maximal clinical effectiveness and tolerability of any treatment option, adjustments are often necessary. This article outlines the "fine-tuning" options available for antiseizure medications, vagus nerve stimulation and ketogenic diet therapies and demonstrates that ketogenic diet therapies offer a wider array of personalizing and fine-tuning options.

Address: University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA. Electronic address: [email protected].; Barrow Neurological Institute at Phoenix Children's, 1919 E. Thomas Rd., Ambulatory Bldg., 3rd Floor, Phoenix, AZ 85016, USA. Electronic address: [email protected].; Johns Hopkins Hospital, Suite 2158 - 200 North Wolfe Street, Baltimore, MD 21287, USA. Electronic address: [email protected].

DOI: 10.1016/j.eplepsyres.2024.107441

Link outs

Subscription / membership required

Full Text Sources:

MeSH Terms: Humans, Diet, Ketogenic, Vagus Nerve Stimulation, Drug Resistant Epilepsy, Anticonvulsants, Treatment Outcome