Regular use of margarine-containing stanol/sterol esters reduces total and low-density lipoprotein (LDL) cholesterol and allows reduction of statin therapy after cardiac transplantation: preliminary observations.

Anne Vorlat, Viviane M Conraads, Christiaan J Vrints

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2005;22(9):1059-62

PMID: 12957617

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Abstract

Seventeen stable cardiac transplant recipients, of whom 16 were on statin therapy, used margarine with stanol/sterol esters. Total cholesterol in the treatment group was lowered from 211 mg/dl (range 168 to 244) to 177 mg/dl (136 to 241) (17% reduction, p = 0.003) and low-density lipoprotein (LDL) cholesterol was reduced from 125 mg/dl (73 to 161) to 98 mg/dl (57 to 146) (22% reduction, p = 0.0006). LDL cholesterol reached the pre-defined cut-off level of 115 mg/dl in 12 of 17 patients and statin dosages were reduced. In 8 of 12 patients, LDL cholesterol remained at <115 mg/dl 6 weeks after statin reduction.

Address: Department of Cardiology, University Hospital of Antwerp, Edegem, Belgium. [email protected]

DOI: 10.1016/s1053-2498(02)01222-6

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MeSH Terms: Adult, Aged, Cholesterol, Cholesterol, LDL, Cholinergic Antagonists, Diet Therapy, Heart Transplantation, Humans, Immunosuppression Therapy, Male, Margarine, Middle Aged, Phytosterols