Prevalence of human papillomavirus in head and neck cancer patients in India: a systematic review and meta-analysis.

Quazi Syed Zahiruddin, Shilpa Gaidhane, Mohammed Alissa, Rakesh Kumar Sharma, Mubarak Alfaresi, Maha F Al-Subaie, Sarvesh Rustagi, Mahalaqua Nazli Khatib, Ahmed Alsayyah, Divya Sharma, Ali A Rabaan, Prakasini Satapathy, Marwan Al-Hajeili, Mithhil Arora, Hashem Abu Serhan, AlKaabi Na

Journal: BMC infectious diseases 2024;24(1):516

PMID: 38783184

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Abstract

BACKGROUND

Human papillomavirus (HPV) is increasingly recognized as a significant risk factor in the development of head and neck cancers (HNCs), with varying prevalence and impact. This study aims to systematically review and analyze the prevalence of HPV in HNCs in India, providing insights into regional variations.

METHODS

A comprehensive literature search was carried out using PubMed, Embase, and Web of Science up to November 10, 2023. Inclusion criteria focused on original research reporting HPV-positive cases among HNC patients in India. We used Nested-Knowledge software, for screening, and data extraction. The modified Newcastle-Ottawa Scale was used for quality assessment of included studies. We pooled the prevalence of HPV among HNC patients and performed a random-effects model meta-analysis using R software (version 4.3).

RESULTS

The search yielded 33 studies, encompassing 4654 HNC patients. The pooled prevalence of HPV infection was found to be 33% (95% CI: 25.8-42.6), with notable heterogeneity (I² = 95%). Analysis of subgroups according to geographical location indicated varying prevalence rates. Specifically, the prevalence was 47% (95% CI: 32.2-62.4) in the eastern regions and 19.8% (95% CI: 10.8-33.4) in the western regions. No evidence of publication bias was detected.

CONCLUSION

The observed considerable regional disparities on the prevalence of HPV in HNC patients in India emphasizes the need for integrated HPV vaccination and screening programs in public health strategies. The findings underline the necessity for further research to explore regional variations and treatment responses in HPV-associated HNCs, considering the impact of factors such as tobacco use and the potential benefits of HPV vaccination.

Address: Center for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospital, Saveetha University, Chennai, India. [email protected].; Medical Laboratories Techniques Department, AL-Mustaqbal University, Hillah, Babil, 51001, Iraq. [email protected].; Division of Evidence Synthesis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher Education, Wardha, India.; One Health Centre (COHERD), Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education, Wardha, India.; Global South Asia Infant Feeding Research Network (SAIFRN), Division of Evidence Synthesis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher Education, Wardha, India.; Department of Ophthalmology, Hamad Medical Corporation, Doha, Qatar. [email protected].; Graphic Era (Deemed to be University), Clement Town, Dehradun, India.; Graphic Era Hill University, Clement Town, Dehradun, India.; Centre of Research Impact and Outcome, Chitkara University, Rajpura, 140417, Punjab, India.; Chitkara Centre for Research and Development, Chitkara University, Himachal Pradesh, 174103, India.; School of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, India.; College of Medicine and Health Science, Khalifa University, 127788, Abu Dhabi, United Arab Emirates.; Sheikh Khalifa Medical City, Abu Dhabi Health Services Company (SEHA), 51900, Abu Dhabi, United Arab Emirates.; Department of Pathology, College of Medicine, Imam Abdulrahman Bin Faisal University, 31441, Dammam, Saudi Arabia.; Department of Medicine, College of Medicine, King Abdulaziz University, 23624, Jeddah, Saudi Arabia.; Research Center, Dr. Sulaiman Alhabib Medical Group, 13328, Riyadh, Saudi Arabia.; College of Medicine, Alfaisal University, 11533, Riyadh, Saudi Arabia.; Department of Microbiology, National Reference laboratory, Cleveland clinic Abu Dhabi, 92323, Abu Dhabi, United Arab Emirates.; Department of Pathology, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, 505055, Dubai, United Arab Emirates.; Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.; College of Medicine, Alfaisal University, 11533, Riyadh, Saudi Arabia.; Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, 31311, Dhahran, Saudi Arabia.; Department of Public Health and Nutrition, The University of Haripur, 22610, Haripur, Pakistan.

DOI: 10.1186/s12879-024-09357-2

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https://medlineplus.gov/headandneckcancer.html

MeSH Terms: Female, Humans, Male, Head and Neck Neoplasms, Human Papillomavirus Viruses, India, Papillomavirus Infections, Prevalence, Risk Factors