Biosynthesis of isonitrile lipopeptides.

Wenjun Zhang, Yiyan Zhou, Kaimin Jia, Helen Sun

Journal: Current opinion in chemical biology 2024;81():102470

PMID: 38788523

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Abstract

Isonitrile lipopeptides discovered from Actinobacteria have attracted wide attention due to their fascinating biosynthetic pathways and relevance to the virulence of many human pathogens including Mycobacterium tuberculosis. Specifically, the identification of the new class of isonitrile-forming enzymes that belong to non-heme iron (II) and α-ketoglutarate dependent dioxygenases has intrigued several research groups to investigate their catalytic mechanism. Here we summarize the recent studies on the biosynthesis of isonitrile lipopeptides from Streptomyces and Mycobacterium. The latest research on the core and tailoring enzymes involved in the pathway as well as the isonitrile metabolic enzymes are discussed in this review.

Address: Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA 94720, United States; California Institute for Quantitative Biosciences, University of California Berkeley, Berkeley, CA 94720, United States.; Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA 94720, United States.; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, United States.; Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA 94720, United States; California Institute for Quantitative Biosciences, University of California Berkeley, Berkeley, CA 94720, United States. Electronic address: [email protected].

DOI: 10.1016/j.cbpa.2024.102470

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MeSH Terms: Lipopeptides, Nitriles, Streptomyces, Humans, Mycobacterium, Biosynthetic Pathways