Loop Diuretics Unique Mechanism of Action.

Agam Vora, Senthilnathan Mohanasundaram, Jps Sawhney, Dharmesh Solanki, Nitin Modi, Tapan Ghose, Anand Kumar, R R Mantri, Febin Francis, Sarita Choudhary, Anurag Singhal, Rajeev Edakutty, Arindam Pande, Ramandeep Ahuja

Journal: The Journal of the Association of Physicians of India 2024;72(9S):14-15

PMID: 39291566

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Abstract

Loop diuretics, including torsemide, furosemide, bumetanide, and piretanide, act by inhibiting the sodium-potassium-chloride (Na/K/2Cl) cotransporter in the thick ascending limb of the loop of Henle within the nephron. This mechanism is pivotal in managing fluid retention associated with conditions such as heart failure, cirrhosis, chronic kidney disease, and hypertension. A comprehensive understanding of how these diuretics uniquely target this transporter provides crucial insights into effectively addressing fluid overload across diverse clinical conditions.

Address: Senior Consultant Interventional Cardiologist, Department of Cardiology, Cardiac Consultant Hospital, Rajkot, Gujarat, India, Corresponding Author.; Consultant Interventional Cardiologist, Department of Cardiology, SMS Hospital, Jaipur, Rajasthan, India.; Chest Physician, Department of Medicine, Vora Clinic, Mumbai, Maharashtra, India.; Director and HOD, Senior Interventional Cardiologist, Department of Medicine, Fortis Hospital, Vasant Kunj, New Delhi, India.; Senior Interventional Cardiologist, Department of Cardiology, Director Cath Lab, Sir Ganga Ram Hospital, New Delhi, India.; Senior Consultant Interventional Cardiologist, Care CHL Hospital, Indore, Madhya Pradesh, India.; Senior Consultant Cardiologist and Chairman of Cardiology, Department of Cardiology, Sir Ganga Ram Hospital, New Delhi, India.; Senior Consultant Interventional Cardiologist, Department of Cardiology, Ajanta Heart Care & Diagnostic Centre, Ghaziabad, Uttar Pradesh, India.; Consultant Interventional Cardiologist, Department of Cardiology, Lakeshore Hospital & Research Centre, Kochi, Kerala, India.; Senior Consultant Cardiologist and HOD, Department of Cardiology, Kozhikode District Co-operative Hospital, Kozhikode, Kerala, India.; Consultant Interventional Cardiologist, Department of Cardiology, Medica Superspecialty Hospital, Kolkata, West Bengal, India.; Interventional Cardiologist, Department of Cardiology, Krishna Hospital & Research Center, Haldwani, Uttarakhand, India.; Medical Advisor, Medical Affairs, Cipla Ltd., Mumbai, Maharashtra, India.; Country Head, Medical Affairs, Cipla Ltd., Mumbai, Maharashtra, India.

DOI: 10.59556/japi.72.0670

MeSH Terms: Humans, Furosemide, Heart Failure, Sodium Potassium Chloride Symporter Inhibitors