ٍEffects of Sumac Consumption on Blood Pressure, Glycemic Indices, and Body Composition in Adults: A GRADE-assessed Systematic Review and Dose-response Meta-analysis.

Seyedeh Nooshan Mirmohammadali, Shaghayegh Taheri, Hossein Bahari, Zahra Sohrabi, Neda Haghighat, Mohammad Hashem Hashempur, Omid Asbaghi, Haniyeh Golafrouz

Journal: Diabetes & metabolic syndrome 2024;18(9):103122

PMID: 39316955

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

Owing to the rich phytochemical content of Rhus coriaria L. (Anacardiaceae), known as Sumac, it may affect blood pressure, glycemic, and anthropometric indices. We, therefore, aimed to examine evidence on effect of Sumac on these factors by conducting a meta-analysis of RCTs.

METHODS

A systematic literature search up to January 2024 was completed in PubMed/Medline, Scopus, and Web of Science. Heterogeneity tests of the selected trials were performed using the I statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as weighted mean differences (WMD) with a 95 % confidence interval (CI).

RESULTS

Fifteen RCTs were included in this meta-analysis. Our findings showed that Sumac consumption significantly reduced diastolic blood pressure (DBP) (WMD = -2.88 mmHg; 95 %CI, -4.22 to -1.54; P = 0.001), fasting blood glucose (FBG) (WMD = -5.15 mg/dL; 95 %CI, -8.73 to -1.57; P = 0.005), insulin (WMD = -1.95 uIU/ml; 95 %CI, 3.11 to -0.79; P = 0.001), Hemoglobin A1c (WMD = -0.48 %; 95 %CI -0.84 to -0.12; P = 0.001), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (WMD = -0.71; 95 %CI, -1.14 to -0.27; P = 0.001), and waist to hip ratio (WHR) (WMD = -0.01; 95 %CI, -0.02 to -0.00; P = 0.017). Sumac consumption had no significant effects on weight, body mass index, and waist circumference.

CONCLUSION

We found that Sumac consumption could improve DBP, glycemic indices, and WHR. Also, supplementation of this herb in higher doses or longer durations had more promising effects on FBG, HOMA-IR, and WHR.

Address: Department of Clinical Biochemistry, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.; Community Nutrition Department, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.; Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: [email protected].; Department of Nutrition Science, Purdue University, West Lafayette, IN, 47907, USA.; Research Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.; Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.; Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: [email protected].; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].

DOI: 10.1016/j.dsx.2024.103122

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MeSH Terms: Humans, Blood Pressure, Glycemic Index, Blood Glucose, Body Composition, Rhus, Plant Extracts, Adult, Prognosis