Building evidence on safety of endovascular thrombectomy for patients under anticoagulation with vitamin K antagonists.

Xiaowei Sun, Li Gao, Peiying Li

Journal: CNS neuroscience & therapeutics 2024;30(7):e14777

PMID: 38958388

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Abstract

A recent study by Brian Mac Grory and colleagues investigated the safety of endovascular thrombectomy (EVT) among patients under vitamin K antagonists (VKAs) use within 7 days prior to hospital admission. Through this retrospective, observational cohort study, they found prior VKA use did not increase the risk of symptomatic intracranial hemorrhage (sICH) overall. However, recent VKA use with a presenting international normalized ratio (INR) > 1.7 was associated with a significantly increased risk of sICH. Future large-scale randomized controlled trials should be conducted to further clarify the effects and feasibility of EVT therapy in ischemic stroke patients under anticoagulation.

Address: Department of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Clinical Research Center, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Clinical Research Center, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Department of Anesthesiology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

DOI: 10.1111/cns.14777

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MeSH Terms: Humans, Vitamin K, Thrombectomy, Anticoagulants, Endovascular Procedures, Ischemic Stroke, Retrospective Studies