Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people.

Address: Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Faculty of International Liberal Arts, Juntendo University, Tokyo, Japan.; Division of International Health Policy Research, Institute for Cancer Control, National Cancer Center, Tokyo, Japan.; Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France.; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Department of General Internal Medicine, Kyushu University Hospital, Fukuoka, Japan.; Department of Comprehensive General Internal Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.; Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.; Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.; Cancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, Japan.; Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.; Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.; Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.; Department of Public Health, Shiga University of Medical Science, Otsu, Japan.; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of International and Community Oral Health, Tohoku University Graduate School of Dentistry, Sendai, Japan.; Division for Regional Community Development, Liaison Center for Innovative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.; Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.; Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University, Iwate, Japan.; Division of Clinical Research and Epidemiology, Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.; Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.; Division of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, Iwate, Japan.; Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.; Department of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.; Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.; Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya, Japan.; Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.; Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.; Aichi Cancer Center Research Institute, Nagoya, Japan.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan.; Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.; Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan.; Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan.; Department of Health Data Science, Graduate School of Data Science, Yokohama City University, Yokohama, Japan.; Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.; National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.; Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.; Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Iwate, Japan.; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.; Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan.; Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan.; Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.; Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France.